M82 was discovered on December 31, 1774 by Johann Elert Bode together with M81; he described it as a "nebulous patch", about 0.75 deg away from M81, which "is very pale and of elongated shape," and cataloged it as No. 18 in his catalog. Pierre Méchain independently rediscovered both galaxies as nebulous patches in August 1779 and reported them to Charles Messier, who added them to his catalog after his position measurement on February 9, 1781.

Forming a most conspicuous physical pair with its neighbor, M81 (THE showpiece galaxies for many Northern hemispherers), this galaxy is the prototype of an irregular of the second type, i.e. a "disk" irregular. Its core seems to have suffered dramatically from a semi-recent close encounter with M81, being in a heavy starburst and displaying conspicuous dark lanes.

M82 belongs to those few Messier objects which have been assigned a Herschel number, H IV.79, based on an observation of September 30, 1802, while William Herschel usually carefully avoided to give his numbers to Messier objects.

Galaxy is easy to observe because her surface brightness is greater than surface brightness of M81. Higher magnification and 6" telescope may show some dark lanes around core of this galaxy.